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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-downassay and in vitro kinase assay.Specifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affectingdownstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell cycle arrest.Our study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway

Keywords： benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

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Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 287-291 doi: 10.1007/s11684-009-0050-5

Abstract: In order to explore the role of cyclin-dependent kinase 4 (cdk4) in neurodegenerative diseases, lentiviral-deliveredThe above recombinants were transfected by lipofectamine into BV-2 cells.The cdk4-siRNA2 was the most effective in silencing cdk4.The optimized pSIH1-cdk4-siRNA2 and pSIH-negative-siRNA were co-transfected into 293T cells with theexpressing cdk4-siRNA was determined by reverse transcriptase-PCR (RT-PCR) and Western blotting in BV-2

Keywords： cyclin-dependent kinase 4     RNA interference     plasmid     lentiviral vector    

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The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 384-389 doi: 10.1007/s11684-009-0070-1

Abstract: In the present report, cyclin-dependent kinase1 (CDK1) siRNA was transfected into cells to silence the

Keywords： cyclin-dependent kinase1     siRNA interference     cell cycle     apoptosis    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: The aim of this study is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation, protein phosphatase 2A (PP2A) activity, and on tau phosphorylation.of Src protein, and the phosphorylation levels of PP2A Y307 and tau at different sites, as well as PP2AHowever, the total PP2A protein level was also decreased, together with a decreased PP2A activity.Multiple factors may be involved in the cellular regulation of PP2A activity.

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylation via TGFBR2.AKT and TGFBR2 inhibition resulted in the reversal of the GDF15-induced expression of UGT1A, indicatingthat TGFBR2-AKT pathway-dependent metabolic pathways were involved in the resistance of ESCC cells to

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2

Keywords： palmitate     characteristic     study     plasma     resistance    

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China’s carbon neutrality: an extensive and profound systemic reform

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 2, doi: 10.1007/s11783-023-1614-3

Abstract:

● China has pledged ambitious carbon peak and neutrality goals for mitigating global climate change.

Keywords： Carbon neutrality     Energy structure     Technology-dependent society     Coordinated mitigation for air pollutantsand CO2    

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Mechanisms of insulin resistance in obesity

Jianping Ye

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 14-24 doi: 10.1007/s11684-013-0262-6

Abstract:

Obesity increases the risk for type 2 diabetes through induction of insulin resistance.Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistanceHowever, none of those concepts or views has led to an effective therapy for type 2 diabetes.The energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated protein kinase

Keywords： type 2 diabetes     energy expenditure     inflammation     lipotoxicity     mitochondria     hyperinsulinemia     adenosinemonophosphate-activated protein kinase (AMPK)    

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Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract:

Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusionRARα) fusion protein, this work was performed to determine the transcription start site of ANXA2The overexpression of ANXA2 in U937 transfected with full-length ANXA2 cDNA was associated with increasedThe tPA-dependent initial rate of plasmin generation (IRPG) in zinc-treated U937/PR9 increased by 2.13Thus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate

Keywords： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

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Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productivesplicing of checkpoint kinase 1

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 186-195 doi: 10.1007/s11705-015-1540-4

Abstract: Increased expression levels of the RNA splicing regulator Transformer2 (abbreviated Tra2 ) have beenRecent work has revealed an intimate cross-regulation between Tra2 and the highly similar Tra2 proteinDown-regulation of Tra2 reduces splicing inclusion of a poison exon in the mRNA encoding Tra2 , therebyup-regulating Tra2 protein expression.These exons include a critical exon within the checkpoint kinase 1 (CHK1) gene that plays a crucial function

Keywords： RNA splicing     gene expression     breast cancer     DNA damage     CHK1    

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Discovery of small molecule degraders for modulating cell cycle

Frontiers of Medicine   Pages 823-854 doi: 10.1007/s11684-023-1027-5

Abstract: Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate theIn this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders.Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein

Keywords： PROTAC     molecular glue     degrader     cell cycle     CDK     cyclin    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 383-388 doi: 10.1007/s11684-016-0488-1

Abstract:

The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming theEGFR C797S mutation, EGFR L718Q mutation, and amplifications of HER-2,MET, or ERBB2.

Keywords： EGFR     tyrosine kinase inhibitor     AZD9291     EAI045    

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Data-driven approach to solve vertical drain under time-dependent loading

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 3,   Pages 696-711 doi: 10.1007/s11709-021-0727-7

Abstract: , the vertical drain consolidation problem is solved by numerous analytical solutions, such as time-dependentDNN–GA prediction models with three different radial drainage patterns in the smear zone under time-dependent

Keywords： vertical drain     artificial neural network     time-dependent loading     deep learning network     genetic algorithm    

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Chloride binding and time-dependent surface chloride content models for fly ash concrete

S. MUTHULINGAM,B. N. RAO

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 1,   Pages 112-120 doi: 10.1007/s11709-015-0322-x

Abstract: models for fly ash concrete, namely: 1) surface chloride content under tidal exposure condition; and 2)

Keywords： binding isotherms     chloride ingress     concrete     fly ash     surface chloride content    

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Title Author Date Type Operation

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Journal Article

The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

China’s carbon neutrality: an extensive and profound systemic reform

Journal Article

Mechanisms of insulin resistance in obesity

Jianping Ye

Journal Article

Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Journal Article

Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productivesplicing of checkpoint kinase 1

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Journal Article

Discovery of small molecule degraders for modulating cell cycle

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Journal Article

Data-driven approach to solve vertical drain under time-dependent loading

Journal Article

Chloride binding and time-dependent surface chloride content models for fly ash concrete

S. MUTHULINGAM,B. N. RAO

Journal Article